B cell chronic lymphocytic leukemia (BCLL) is one of the most widespread leukemias. There is a controversy about whether a single or double B cell subset gives rise to BCLL, or whether the cells are at the same or different stages of maturation at the time of transformation. To refer to the various stages of activation and differentiation of B cells, the expression of IgD and CD38 are used.
B cell chronic lymphocytic leukemia is a type of slow growing leukemia that affects developing B-lymphocytes (also known as B-cells). These specialized white blood cells under normal conditions produce antibodies that are also known as immunoglobins. They play an integral role in protecting our body against infection and disease. In some cases, B cell chronic lymphocytic leukemia remains stable for many months and years, thus not affecting the person’s general health and lifestyle. Some people despite their diagnosis manage to continue leading a normal life without any treatment for many years.
For others, B cell chronic lymphocytic leukemia or the leukemic cells multiply in an uncontrolled way. As they are abnormal cells, they don’t function properly. Additionally, they live longer than they should and accumulate in the bone marrow, liver, lymph nodes, spleen, and other body parts. As a result, the excess number of lymphocytes in the bone marrow starts interfering with the normal blood cell production. As the bone marrow starts producing an inadequate number of red blood cells, platelets, and white blood cells, a person becomes more susceptible to anemia, bleeding, bruising, and recurrent infections.
CLL or BCLL is a slow-growing disease showing no symptoms, especially in the early stages, doctors recommend regular check-ups for keeping it at bay. Treatment commences when the disease starts to progress or starts causing troublesome symptoms. Treatment as per the condition and the stage can range from chemotherapy to steroids in some cases. Drugs prescribed target abnormal lymphocytes and don’t cause harmful side effects to other parts of the body. Stem cell transplant also serves as a reliable treatment option for some younger patients. In addition, a number of supportive therapies also treat CLL symptoms.