Asthma is a common chronic disease which affects approximately 26 million people in the US alone. It is the most common chronic disease in childhood, affecting an estimated 7 million children. The chronic asthma pathophysiology is complex and involves inflammation of the airway, intermittent obstruction of airflow, and bronchial hyper-responsiveness.
Chronic asthma pathophysiology
Several factors such as allergens emotions medications, physical exertion, stress and occupational infection can trigger asthma. In response to the triggers, mast cells of the immune system that are found lose connective tissue, release vasoactive chemical mediators- an action on vessels. It also releases bradykinin, histamine, cytokines, leukotrienes, and prostaglandins.
The mast cells also release chemotactic( responsible for specific cell movement) chemical mediators that cause lymphocytes, neutrophils, and eosinophils to penetrate the cells of the bronchial lining. These eventually move on to attack the respiratory system to cause several issues such as vascular congestion, bronchoconstriction, vasodilation, mucosal edema, increase in capillary permeability, hampered mucociliary action (removes mucus and contaminants within the bronchial tree with the help of the cilia present in the bronchioles), and increased mucus production. All these factors cause increased resistance in the airway. The extreme production of mucus may also occur in the smaller bronchioles.
In other words, chronic asthma pathophysiology factors include wheezing and respiratory distress. It is essential to understand that the pathology associated with inflammation and remodeling in case of severe asthma becomes highly imperative.
To understand your condition, you will have to consult a specialist. Here, we have compiled a short list of clinics that may help you avail a specialist and get treatment for asthma.
- The Allergy & Asthma Center, Fort Wayne, Indiana
- Atlanta Allergy & Asthma, Atlanta
- Mayo Clinic- It has a presence in several cities across the US such as Phoenix, Scottsdale, Jacksonville, Rochester and several other locations in many states
- Houston Allergy and Asthma Clinic, Houston, Texas
- Cleveland Clinic, Cleveland, Ohio
- Bethesda Allergy & Asthma Clinic, Bethesda MD
- Allergy & Asthma Center of Montana, Great Falls, MT
- Asthma Clinic | UCSF Medical Center, California
Asthma is a chronic condition, and a person may have to be on medications throughout his life.